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Study protocols
Standard protocols in Purkinje fibres or papillary muscle:
- Six preparations
- Four cumulative increasing concentrations of assay compound
- Washout period or positive control
- Two stimulation rates : 1 Hz and 0.2 Hz.
- Normal [K+]ext
NEW!!! TRIaDs
T : Triangulation
R : Reverse-use-Dependency
I : Instability
D : Dispersion
Standard hERG assay protocol:
- Six cells
- Four or three cumulative increasing concentrations of assay compound
- Depolarizing protocol :
Other experimental conditions:
- External hypokaliemic conditions
- Incremental stimulation rates
- Compounds interaction