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Compounds interaction: Investigation of the putative interaction between two drugs on the hERG channels at therapeutic concentrations and their consequences on the action potential prolongation

Indeed, PhysioStim focused on ziprasidone, an atypical antipsychotic devoided of cardiac adverse effects in spite of its propensity to prolong the QT-interval via a hERG current inhibition. Moreover, very little information is available concerning pharmacodynamic interactions between ziprasidone and other hERG channel blockers. Thus, we investigated the putative interaction between ziprasidone and d,l-sotalol on the hERG channels at therapeutic concentrations and their consequences on the action potential prolongation.

 

Effects of ziprasidone 10 µmol/L superfused alone (panel A) or in association with d,l-sotalol 10 µmol/L (panel B) on hERG channel inhibition.
Zip: ziprasidone; sot: d,l-sotalol. Currents were recorded at room temperature. Pulses cycling rate was 30 s.