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ECG recordings: effects induced by the test article on left ventricular cardiac functions and cardiac electrical activity in isolated Langendorff perfused guinea-pig hearts

 

Coronary flow: indicated by the perfusion pressure-controlled peristaltic pump (mL/min)

 

Left ventricular pressure parameters:

Systolic pressure, end diastolic pressure (mmHg)
Developed pressure: maximal systolic pressure - minimal diastolic pressure (mmHg)
Max dP/dt: maximal contraction velocity (mmHg/s)
Min dP/dt: maximal relaxation velocity (mmHg/s)
PR, QRS, RR and QT interval (ms)
QTc intervals: Bazett (QT / (RR)^1/2) and/or Fredericia (QT / (RR)^1/3)

Tpe interval: dispersion of repolarisation (ms)
Tpe/QT ratio: predictive marker of arrhythmia vulnerability
Heart rate: calculated from ventricular contractions or from ECGs (beats/min)

 

Electrocardiograms, left ventricular pressure parameters and coronary flow are recorded in hearts perfused at a constant pressure of 63 +/- 3 mmHg.

 

ECG recordings in ischaemic conditions (low coronary flow).