- PhysioStim's letters
- Newsletters
Do you know why safety pharmacology studies are essential ?
Apart from some cardiovascular medicinal products that are well recognized to be proarrhythmogenic in certain circumstances, there are a number of other therapeutic classes of compounds that have been known to cause serious and potentially fatal proarrhythmias.
These include, amongst others, antipsychotics, antihistamines, diuretics, gastrointestinal prokinetics, antidepressants, anticonvulsants, antibiotics, antimalarials, antimycotics, antiasthmatics, anticancer drugs...Medicinal products that prolong the cardiac repolarisation have been associated with a specific, potentially fatal polymorphic ventricular tachycardia termed "Torsades de pointe" (TdP).
Several animal studies showed that an increasing number of non-cardiovascular target molecules causes potential risk for QT interval prolongation, and that they could also initiate "torsades de pointe".
