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 Measured parameters

 

• hERG assay

• Action Potential recordings in Purkinje fibers or papillary muscle

Supplementary parameters recorded in the following models :

- In atria

- In papillary muscle : Excitation-Contraction coupling

 

Action potentials recordings in Purkinje fibers or papillary muscles :

Resting Potential (RP)
Maximal rate of depolarisation (dV/dt_max)
Action potential amplitude (APA)
Action potential Duration at 50%, 70% and 90% of repolarisation (APD₅₀, APD₇₀ and APD₉₀)
APD_90-40, APD₄₀ if necessary