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Overview

NEED HELP WHEN SELECTING YOUR COMPOUNDS AT A PRECLINICAL STAGE?

NEED TO DETERMINE EARLY COMPOUNDS CAPABLE OF INDUCING QT PROLONGATION?

 

PhysioStim has the relevant expertise to help you.

Since 2000, PhysioStim – one of the European’s most reliable French CRO (Contract Research Organisation) –has never ceased to improve its expertise in cardiac safety pharmacology.

Indeed, PhysioStim’s experts offer electrophysiological studies, preclinical resources as well as their dedicated expertise in answering ICHS7A and S7B guidelines in accordance with GLPs (Good Laboratory Practices).

PhysioStim therefore offers a wide range of services and consequently improves the quality of work.

Relationship between action potential recordings, arrhythmias (Early After Depolarization) and ECG. In vitro effects (increase in action potential duration) are predictive of the occurrence of Torsades de Pointes in vivo (TdPs).

Rationale for safety studies:

• Scientifically valid methods to be used
• Safety pharmacological studies to be performed by a specialized unit working under GLP conditions