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Experimental models

 

Action potentials from :

• Isolated rabbit Purkinje fibre
• Isolated dog Purkinje fibre
• Isolated rabbit atria
• Guinea-Pig papillary muscle
• Excitation-Contraction coupling

Channel protein of human heart in vitro :

• Na_v1.5 assay on Human Embryonic Kidney (HEK) cells
• hERG channel assay on Human Embryonic Kidney (HEK) cells
• K_vLQT₁ channel assay on Human Embryonic Kidney (HEK) cells

Compounds interaction

Cytosolic Ca²⁺ fluorometry