Additional preclinical assays for cardiac safety studies

GLP-certified expertise in cardiovascular pharmacology & electrophysiology

Additional study models for preclinical safety assays

PhysioStim offers a wide selection of preclinical cardiac safety assays in compliance with all ICH S7A and S7B guidelines and Good Laboratory Practices. We are a preclinical Contract Research Organization of highly experienced cardiovascular pharmacology and electrophysiology experts. The experts at PhysioStim provide a wide range of possibilities to conduct both your mandatory and complementary assays for reliable and efficient cardiac safety studies:

Isolated organ baths

Between early hERG screening assays and high-cost in vivo telemetry studies, the isolated organ bath set-up offers an affordable ex vivo model to detect drug-​induced effects on contractility.

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Telemetry studies

Cardiac telemetry studies measure cardiovascular activities in conscious animals in a controlled environment, in compliance with the ICH S7B guideline.

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In silico studies

In silico models allow the reconstruction of the electrophysiological activity within a heart cell. In silico studies comply with the upcoming CIPA regulations on preclinical safety.

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Our entire range of cardiac safety assays

A wide selection for reliable preclinical safety studies

The experts at PhysioStim go beyond standard study guidelines to conduct their safety studies. We provide a wide range of possibilities to conduct both mandatory and complementary studies and help your project move forward. PhysioStim has over 17 years of expertise in developing in vitro and ex vivo models to investigate potential drug-related cardiac adverse effects. We provide cellular models as well as tissue and organ models.

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