a history in excellence
Cardiovascular pharmacology & electrophysiology at its best
PhysioStim is an independent preclinical CRO with high-level expertise in the field of cardiovascular pharmacology and electrophysiology. The company was founded in the year 2000 by Dr. Marie Le Grand, our CEO, and is located in the beautiful village of Lautrec in Southern France. Through PhysioStim, Dr. Le Grand aims to address the growing need of the pharmaceutical industry and biotech companies to conduct high quality preclinical assays and studies. Over the years, PhysioStim has grown into a highly valued team that rises to the challenge of designing and conducting high quality studies for drug development and validation. Our scientists are recognized for their expertise, reactivity, motivation and awarded with the loyalty of a consistently growing customer base.
“One-to-one customer relations are key to our business. We value our customers and guide their preclinical studies with innovative, robust ideas. Our main goal is to deliver state-of-the-art cardiovascular safety studies while providing excellent customer service.”
Creation of Physiostim for microelectrode assays
First GLP certificate
GLP grade A certificate
Launch patch clamp & hERG assays
Launch of Langendorff assays
Ethical committee animal experiments US006 / CREFRE
Launch of isolated organ assays
Alliance with Apconix
Marie Le Grand, PhD
CEO & Founder
Before founding PhysioStim in 2000, Dr. Le Grand worked in collaboration with the French Muscular Dystrophy Association AFM. She completed her experience in electrophysiology in the team of Prof. Coraboeuf at the Orsay University of Sciences in Paris, France. In 1992, Dr. Le Grand received her PhD in Animal Physiology from the Pierre and Marie Curie University in Paris VI, France. She also obtained a Master’s degree in cardiovascular pharmacology from the Claude Bernard University in Lyon, France, in 1988.
CSO & Head of the Patch Clamp Laboratory
With more than 14 years of experience at PhysioStim, Richard is one of our most qualified Study Director of in-vitro preclinical GLP studies on cardiovascular safety. He obtained a Master of Science in pharmacology and physiology at the University of Poitiers (France) in 2003 ended by an 8 months internship in cardiovascular research division of Pierre Fabre, and joined PhysioStim at the end of his University Course.
Richard has also received expert training to direct non-clinical studies and R&D projects as well as multisite studies within the GLP framework.
Study Director of Patch Clamp Studies
Stéphanie has been PhysioStim’s Study Director of patch-clamp studies since 2005. She has more than 12 years experience in patch clamp electrophysiology and holds a Master of Science in pharmacology and physiology from the University of Poitiers (France) in 2005, followed by an internship in cardiovascular research division of Pierre Fabre.
Stéphanie has also received expert training to direct non clinical studies and R&D projects as well as multisite studies within the GLP framework.
Study Director of Microelectrode, Langendorff Isolated Perfused Heart & Isolated Organ baths Studies
Céline has been our Study Director since January 2005. As a member of the ethics committee for animal protection used for scientific purposes, she’s also responsible for the animals in our studies. Céline holds a Bachelor of Science degree in physiology in 2004 from the Paul Sabatier University of Toulouse, France.
Céline has also received expert training to direct non clinical studies and R&D projects as well as multisite studies within the GLP framework.
Study Director of Langendorff Isolated Perfused Heart & Isolated Organ Bath Studies
Hélène joined PhysioStim in January 2010 as Study Director of Isolated Langendorff Perfused Heart studies. She has a Master of Science in physiology and pharmacology from the University of Poitiers (France) in 2008. She also spent one year as a neuroscience researcher of the physiopathology of neuronal plasticity at the INSERM research laboratory of Bordeaux, France.
Hélène has also received expert training to conduct non clinical studies and R&D projects as well as multisite studies within the GLP framework.
Frédéric holds a Master of Science degree in pharmacology and pathophysiology from the University of Nice in France. He began his career as a Biology Research Engineer, managing scientific projects within the French CNRS and INSERM research institutions for 10 years. Frédéric then added a Pharmacovigilance Degree to his training and took up the position of Drug Safety Scientist within Regional PharmacoVigilance Center CRPV, an organization attached to the French ANSM health authorities. He subsequently obtained an MBA from the IAE School of Management in Lyon, France. Frédéric worked as a Business Development Manager on strategic aspects of sales within the International Operations & Business development department of a pharmaceutical company before becoming Key Account Manager for a pan-European supplier of innovative reagents and laboratory services for the life science sector. Frederic joined the PhysiosTEAM in 2018.
Khadija joined part-time PhysioStim in August 2011. She ensures the maintenance of facilities, the animal units and the relative equipment.