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a history in excellence

Cardiovascular pharmacology & electrophysiology at its best

Company history

PhysioStim is an independent preclinical CRO with high-level expertise in the field of cardiovascular pharmacology and electrophysiology. The company was founded in the year 2000 by Dr. Marie Le Grand, our CEO, and is located in the beautiful village of Lautrec in Southern France. Through PhysioStim, Dr. Le Grand aims to address the growing need of the pharmaceutical industry and biotech companies to conduct high quality preclinical assays and studies. Over the years, PhysioStim has grown into a highly valued team that rises to the challenge of designing and conducting high quality studies for drug development and validation. Our scientists are recognized for their expertise, reactivity, motivation and awarded with the loyalty of a consistently growing customer base.

“One-to-one customer relations are key to our business. We value our customers and guide their preclinical studies with innovative, robust ideas. Our main goal is to deliver state-of-the-art cardiovascular safety studies while providing excellent customer service.”

dr. marie le grand
CEO

Milestones

2000
2001
2003
2005
2009
2013
2015
2017

2000

Creation of Physiostim for microelectrode assays

2001

First GLP certificate

2003

GLP grade A certificate

2005

Launch patch clamp & hERG assays

2009

Launch of Langendorff assays

2013

Ethical committee animal experiments US006 / CREFRE

2015

Launch of isolated organ assays

2017

Alliance with Apconix

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Our team

Marie Le Grand, PhD

CEO & Founder

Before founding PhysioStim in 2000, Dr. Le Grand worked in collaboration with the French Muscular Dystrophy Association AFM. She completed her experience in electrophysiology in the team of Prof. Coraboeuf at the Orsay University of Sciences in Paris, France. In 1992, Dr. Le Grand received her PhD in Animal Physiology from the Pierre and Marie Curie University in Paris VI, France. She also obtained a Master’s degree in cardiovascular pharmacology from the Claude Bernard University in Lyon, France, in 1988.

Richard Printemps

Head of the Patch Clamp Laboratory

After more than 14 years of experience at PhysioStim, Richard is one of our most qualified Study Director of in-vitro preclinical GLP studies on cardiovascular safety. He obtained a Master in Science degree in pharmacology and physiology at the University of Poitiers (France) in 2003 ended by an 8 months internship in cardiovascular research division of Pierre Fabre, and joined PhysioStim at the end of his University Course.

Richard has also received expert training to direct non-clinical studies and R&D projects as well as multisite studies within the GLP framework.

Stéphanie Guilbot

Study Director of Patch Clamp Studies

Stéphanie has been PhysioStim’s Study Director of patch-clamp studies since 2005. She has more than 12 years experience in patch clamp electrophysiology and holds a Master in Science degree in pharmacology and physiology from the University of Poitiers (France) in 2005 ended by an internship in cardiovascular research division of Pierre Fabre.

Stéphanie has also received expert training to direct non clinical studies and R&D projects as well as multisite studies within the GLP framework.

Céline Salvetat

Study Director of Microelectrode, Langendorff Isolated Perfused Heart & Isolated Organ baths Studies

Céline has been our Study Director since January 2005. As a member of the ethics committee for animal protection used for scientific purposes, she’s also responsible for the animals in our studies. Céline holds a Bachelor of Science degree in physiology in 2004 from the Paul Sabatier University of Toulouse, France.

Céline has also received expert training to direct non clinical studies and R&D projects as well as multisite studies within the GLP framework.

Hélène Didier

Study Director of Langendorff Isolated Perfused Heart & Isolated Organ Bath Studies

Hélène joined PhysioStim in January 2010 as Study Director of Isolated Langendorff Perfused Heart studies. She has a Master of Science degree in physiology and pharmacology from the University of Poitiers (France) in 2008. She also spent one year as a neuroscience researcher of the physiopathology of neuronal plasticity at the INSERM research laboratory of Bordeaux, France.

Hélène has also received expert training to conduct non clinical studies and R&D projects as well as multisite studies within the GLP framework.

Myriam Crambes

Quality Assurance Manager

Myriam joined PhysioStim in February 2003, as our Quality Assurance Manager. She has a BTEC Higher National Diploma in Biotechnology and a Master’s degree in Quality Assurance in 2002 from the University of Tours, France.

Brigitte Pradelles

Maintenance

Brigitte was the first employee to integrate part-time our company in June 2000. She ensures the maintenance of premises and those of the animal units and all the relative equipment.

Khadija El Ouahidi

Maintenance

Khadija joined part-time PhysioStim in August 2011 as a supplement to Brigitte to ensure the maintenance of facilities.

For more information on our qualifications and services

Don’t hesitate to contact us