GLP-certified expertise in cardiovascular pharmacology & electrophysiology

The right study model for all your ion channel assays

PhysioStim offers a wide selection of ion channel assays as well as additional cardiac safety studies in compliance with all ICH S7A and S7B guidelines and Good Laboratory Practices. We are a preclinical Contract Research Organization of highly experienced cardiovascular pharmacology and electrophysiology experts. The experts at PhysioStim provide a wide range of possibilities to conduct both your mandatory and complementary ion channel assays for reliable and efficient cardiac safety studies.

Expert hERG assays

hERG assays are mandatory during preclinical safety studies because they are involved in the long QT syndrome of type 2 (LQT2 syndrome). They aim to identify potential inhibitory effects early on in the drug discovery process.

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Sodium channel assays

The human NaV1.5 sodium channel is another major target to assess cardiac safety involved in the long QT syndrome (LQT3 syndrome or Brugada syndrome). These assays detect potential reductions in cardiac conduction.

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Calcium channel assays

The CaV1.2 calcium channel conducts electrical current across the cell membrane and is involved in the long QT syndrome of type 8 (LQT8 syndrome). Assays on this channel aim to prevent drug-related cardiac arrythmias.

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Other potassium channel assays

Additional hKvLQT1/MinK, hKv4.3 and hKv1.5 potassium channel assays may be required to determine or validate cardiovascular safety and are involved in LQT1, LQT5 syndromes.

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Our entire range of cardiac safety assays

A wide selection for reliable preclinical safety studies

The experts at PhysioStim go beyond standard study guidelines to conduct their safety studies. We provide a wide range of possibilities to conduct both mandatory and complementary studies and help your project move forward. PhysioStim has over 17 years of expertise in developing in vitro and ex vivo models to investigate potential drug-related cardiac adverse effects. We provide cellular models as well as tissue and organ models.

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