Expert preclinical safety studies

High-level expertise and partnerships for reliable safety studies

PhysioStim, experts in cardiovascular safety studies

PhysioStim is one of Europe’s most reliable Contract Research Organizations for cardiac safety pharmacology.

Our experts offer electrophysiological studies, preclinical resources as well as their dedicated expertise in answering ICH S7A and S7B guidelines in accordance with GLP (Good Laboratory Practices).

High quality cardiovascular pharmacology and electrophysiology studies for drug development.

We help pharmaceutical & biotech companies:

  • Derisk compounds at an early stage
  • Help them to select the lead candidates during the preclinical stage
  • Determine early compounds able to induce QT prolongation

Your expert for all cardiac safety assays

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MANDATORY PRECLINICAL STUDIES

GLP-certified preclinical ICH S7B & S7A-compliant assays

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FOLLOW-UP STUDIES TO COMPLETE YOUR DATA

A wide range of in vitro and in vivo assays for cardiac safety studies

The right study model to guarantee excellence

A wide selection for reliable preclinical safety studies

The experts at PhysioStim go beyond standard study guidelines to conduct their safety studies. We provide a wide range of possibilities to conduct both mandatory and complementary studies and help your project move forward. PhysioStim has over 17 years of expertise in developing in vitro and ex vivo models to investigate potential drug-related cardiac adverse effects. We provide cellular models as well as tissue and organ models.

Specialist partners to cover all aspects of your study

To offer the full range of preclinical safety studies and guarantee High Quality Screening (HTS) services on the main human cardiac ion channels throughout your entire study, we work with a carefully selected range of top experts from various fields.

Amati Group Logo, preclinical safety study partner

GLP formulation analysis (development, validation of a method and formulation analysis, determination of compound in collected samples, solubility and stability study).

Apconix logo preclinical safety study partner

High throughput (HTS) ion channel screening services on the main human cardiac ion channels panel involved in the CiPA initiative (hERG, Nav1.5, Cav1.2, KvLQT1/​MinK, Kir2.1, Kv4.3) and also on a wide range of other ion channels screening assays.

atlanbio logo preclinical safety study partner

GLP formulation analysis (development, validation of a method and formulation analysis, determination of compound in collected samples, solubility and stability study).

Axiogenesis logo preclinical safety study partner

Provider of human cardiomyocytes and High Throughput Screening (HTS) monitoring of the physiological function in the iPSC-​derived cardiomyocytes.

Biotrial logo preclinical safety study partner

In vivo models from anaesthetised and non-anaesthetised animals (multi-frequency telemetry recording in pair-housed animals, high quality ECG in chronically-instrumented animals).

Eurofins logo preclinical safety study partner

GLP formulation analysis (development, validation of a method and formulation analysis, determination of compound in collected samples, solubility and stability study).

Pluriomics logo preclinical safety study partner

Provider of human cardiomyocytes and High Throughput Screening (HTS) monitoring of the physiological function in the iPSC-​derived cardiomyocytes.

Need more information on our company & preclinical expertise ?

Don’t hesitate to contact us