Physiostim, Your expert in preclinical cardiac electrophysiology

PhysioStim offers a wide selection of ion channel assays as well as additional cardiac safety studies in compliance with all ICH S7A and S7B guidelines and Good Laboratory Practices. We are a preclinical Contract Research Organization of highly experienced cardiovascular pharmacology and electrophysiology experts. The experts at PhysioStim provide a wide range of possibilities to conduct both your mandatory and complementary ion channel assays for reliable and efficient cardiac safety studies. We also respect the 3R principle and have already taken steps to comply with the upcoming CIPA guidelines.

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Publications by PhysioStim experts

Human Cardiomyocytes Roundup

Assessment of Roundup® cardiotoxicity on guinea-pig isolated Langendorff perfused heart and human lnduced Pluripotent Stem Cells derived cardiomyocytes

Human Cardiomyocytes aconitine resveratrol

Effects of resveratrol on aconitine-induced cardiac arrhythmia in human induced pluripotent stem cell derived cardiomyocytes

Human Cardiomyocytes Pentamidine Pilsicainide

Evaluation of two hERG channel trafficking modulators, pentamidine and pilsicainide, on stably transfected cell line and human induced pluripotent stem cell-derived cardiomyocytes

Preclinical tool for CARDIAC SAFETY assessment

A preclinical CRO: scientific team graduated in cardiac electrophysiology, reliable and high level of expertise in cardiac safety, GLP compliant since 2001, standardized and customized full services ...

IKs Current in Repolarization Reserve

Role of Cardiac IKs Current in Repolarization Reserve Process During Late Sodium Current (INaL) Activation