Human cardiomyocytes hCM hiPSC-CM cardiomyocytes Human

Human iPSC Cardiomyocytes

Human cardiomyocytes derived from iPS cells for Pharmacological studies

Human cardiomyocytes derived from induced pluripotent stem cells (hiPSC-CM) provide rapid, reproducible and sensitive predictions of pharmacological effect on human normal and diseased cardiac tissue. It is also an integrative system that could easily identify potential cardiotoxic, cardioprotective, anti-arrhythmogenic, pro-arrhythmogenic, chronotropic and inotropic effects of compounds. Because the model is high throughput it is relevant to investigate series of compounds that could support you with ranking selection of candidates based on human pharmacology.

Human iPSC Cardiomyocytes & Pharmacology

Human cardiomyocytes derived from iPS cells provide the best solution to study the repercussion on ion channels and contractility during drug discovery and preclinical studies. This human in vitro model is used to evaluate the electrophysiology and the contractility of cardiomyocytes (normal and diseased). Abnormal cardiac situations such as tachycardia, bradycardia, contractility depression or medication toxicity could be mimicked by using various tools.

What is the added value of such a study?

  • Threshold of investigated pharmacological concentration.
  • Leading to the determination of the safety range versus efficacious concentration
  • To analyze drugs effects on excitation and contraction coupling in human heart
  • Ranking your compounds


  • xCELLigence RTCA Cardio ECR platform (48 wells plate format)
  • iCell®Cardiomyocytes² (Fujifilm)
  • Simultaneous recording of Electric Field Potential (EFP) and Impedance signals on the entire plate:
    -EFP= Reflecting electrical activity

    -Impedance= Reflecting cell contraction

  •  Short and Long term exposure (up to 72h)
  • Disease Models (Option)
    -Brugada Syndrome

    -Dilated Cardiomyopathy

    -Hypertrophic Cardiomyopathy

    -Catecholaminergic Polymorphic Ventricular Tachycardia

Measured Parameters

  • Cell viability: Cell Index
  • Electrophysiology (EFP)
    -Firing rate

    -FPD as predictor of QT duration

    -Spike amplitude

  • Contraction (Impedance)
  • -Amplitude of contraction

    -Beating rate

    -Individual beat duration (IBD10, 50, 90)

    -Proarrhythmic events (BRI)

  • Upon Request : Biomarkers assays

Main advantages

  • Human tissue
  • Adjustable to your needs, manage the concentration and replication of each compound in the 48 wells.
  • Technically robust
  • Highly informative
  • Strongly replicable

Reference compounds

  • Nifedipine
  • E-4031
  • Pentamidine
  • Dofetilide
  • Flecainide
  • Mexiletine
  • Pilsicainide



Predicting risk of chemotherapy- Cell Viability and Incidence of arrhythmias


Predicting risk of chemotherapy- Cell Viability and Incidence of arrhythmias

Cell Viability

Incidence of arrhythmias

Request a quote

    I accept that the information entered in this contact form is used and processed so that PhysioStim can contact me to answer my request.(required)

    Need help with your preclinical safety studies?

    contact us